| | Date | Opponent | | Score | | | Overall | Conference | Attend | Goals scored |
| | Aug 20, 2010 | vs St. John's | W | 1-0 | | | 1-0-0 | 0-0-0 | | Stander, Olivia (Steinlage, Annie) |
| | Aug 22, 2010 | vs #1 North Carolina | | 0-3 | L | | 1-1-0 | 0-0-0 | | - |
| | Aug 29, 2010 | W. MICHIGAN | W | 1-0 | | | 2-1-0 | 0-0-0 | 1026 | Heyboer, Laura (Pines, Megan) |
| | Sep 03, 2010 | EASTERN MICHIGAN | W | 4-0 | | | 3-1-0 | 0-0-0 | 702 | Stander, Olivia (Heyboer, Laura) |
| | | | | | | | | | | Heyboer, Laura (Mueller, Jordan) |
| | | | | | | | | | | Dennis, Mikki (Heyboer, Laura;Kassab, Kelsey) |
| | | | | | | | | | | Kassab, Kelsey (unassisted) |
| | Sep 05, 2010 | at Milwaukee | | 2-3 | L | | 3-2-0 | 0-0-0 | 312 | Heyboer, Laura (Pines, Megan) |
| | | | | | | | | | | Stander, Olivia (Pines, Megan) |
| | Sep 10, 2010 | DEPAUL | | 0-0 | T | O2 | 3-2-1 | 0-0-0 | 925 | - |
| | Sep 12, 2010 | LOYOLA (CHICAGO) | W | 3-0 | | | 4-2-1 | 0-0-0 | 533 | Heyboer, Laura (Stander, Olivia) |
| | | | | | | | | | | Peterson, Hannah (Mullen, Kelsey) |
| | | | | | | | | | | Stander, Olivia (Steinlage, Annie) |
| | Sep 17, 2010 | at Bowling Green | W | 2-0 | | | 5-2-1 | 0-0-0 | 223 | Heyboer, Laura (Peterson, Hannah) |
| | | | | | | | | | | Stander, Olivia (Steinlage, Annie) |
| * | Sep 26, 2010 | at Penn State | | 0-1 | L | | 5-3-1 | 0-1-0 | 1692 | - |
| * | Oct 01, 2010 | INDIANA | W | 2-0 | | | 6-3-1 | 1-1-0 | 274 | Stander, Olivia (Steinlage, Annie;Pines, Megan) |
| | | | | | | | | | | Heyboer, Laura (Stander, Olivia) |
| * | Oct 03, 2010 | PURDUE | W | 2-0 | | | 7-3-1 | 2-1-0 | 420 | Heyboer, Laura (Peterson, Hannah) |
| | | | | | | | | | | Heyboer, Laura (Stander, Olivia) |
| * | Oct 09, 2010 | at Michigan | | 0-0 | T | O2 | 7-3-2 | 2-1-1 | 1077 | - |
| | Oct 14, 2010 | at Oakland University | W | 2-0 | | | 8-3-2 | 2-1-1 | 313 | Heyboer, Laura (penalty kick) |
| | | | | | | | | | | Heyboer, Laura (Stander, Olivia) |
| * | Oct 17, 2010 | NORTHWESTERN | W | 1-0 | | | 9-3-2 | 3-1-1 | 925 | Stander, Olivia (Freeman, Cara;Peterson, Hannah) |
| * | Oct 22, 2010 | at Wisconsin | | 0-2 | L | | 9-4-2 | 3-2-1 | 429 | - |
| * | Oct 24, 2010 | at Minnesota | | 1-1 | T | O2 | 9-4-3 | 3-2-2 | 484 | Stander, Olivia (Peterson, Hannah) |
| * | Oct 29, 2010 | #16 ILLINOIS | | 0-1 | L | | 9-5-3 | 3-3-2 | 310 | - |
| * | Oct 31, 2010 | IOWA | | 1-1 | T | O2 | 9-5-4 | 3-3-3 | 502 | Pines, Megan (Freeman, Cara;Chaklos, Katelin) |
| * | Nov 05, 2010 | at #23 Ohio State | | 0-1 | L | | 9-6-4 | 3-4-3 | 662 | - |
